Macedonia's members began worshipping together in the 1790s & built the extant church structure in 1849. Macedonia Church was the central site of this Free Black community's self-determination, self-sufficiency, and power -- functioning as the focal communication hub, the schoolhouse where children were educated, a night school where adults were taught reading & writing, a "courthouse" where community disputes were internally resolved, a hall where social events took place, and a co-op where Macedonia's farmers were aided & advised on how to distribute harvested crops throughout their Free Black Settlement, and of course, a religious gathering & worship site -- at a time when Ohio's Black Laws and active slavecatcher gangs existed.

Macedonia Church & Settlement members courageously worked the front lines of the Underground Railroad. Macedonia became a natural gateway to the UGRR from southern slave states - often the first stop for freedom seekers escaping slavery in VA [now WV] & KY as they crossed the "River Jordan" (the Ohio River) to the "Promised Land" (northern free territory). Macedonia is well-documented aiding & assisting those seeking liberation, sanctuary, and safety, its ministers & members often guiding individuals through the woods to other UGRR stations and welcoming self-emancipated, manumitted, and free-born Black folks into their established, thriving settlement.

Macedonia Church was listed on the National Register of Historic Places in 1978. Macedonia Church was awarded an Ohio Historical Marker in 2003. The Church was listed as one of Ohio's Most Endangered Historic Sites in 2020. Macedonia Free Black Settlement Cemetery was awarded an Ohio Historical Marker through a generous grant from the William G. Pomeroy Foundation in 2021. Macedonia Church was added to the National Park Service Underground Railroad Network to Freedom Program in 2020. Macedonia was featured on PBS's Finding Your Roots (John Legend Episode; Season 1 Ep.9, 2012).

Macedonia Church was spotlighted at The Dr. Carter G. Woodson Lyceum Black History Institute at Marshall University 2020 & 2021, the Appalachian Studies Association Conference: Toward Antiracism in Appalachian Studies 2021, on Heritage Ohio's "Preservation Shorts" Webinar (2021, 31:31), and discussed during The McKinney Center's event "Useable Past: Spotlighting Successful Regional Development" (25:40). Macedonia was a final round competitor for The National Trust for Historic Preservation's America's 11 Most Endangered Historic Places in 2021; it was selected to re-submit a full nomination in 2022. The Macedonia Settlement Cemetery, along with the courageous United States Colored Troops resting in the sacred burial grounds, was spotlighted at the Army Corps of Engineers' Black History Month event in February 2022.